Background: Cardiovascular disease (CVD) imposes much mortality and morbidity worldwide. The use of â??deep\nlearningâ?, advancements in genomics, metabolomics, proteomics and devices like wearables have the potential to\nunearth new insights in the field of cardiology. Currently, in Asia, there are no studies that combine the use of\nconventional clinical information with these advanced technologies. We aim to harness these new technologies to\nunderstand the development of cardiovascular disease in Asia.\nMethods: Singapore is a multi-ethnic country in Asia with well-represented diverse ethnicities including Chinese,\nMalays and Indians. The SingHEART study is the first technology driven multi-ethnic prospective population-based\nstudy of healthy Asians. Healthy male and female subjects aged 21â??69 years old without any prior cardiovascular\ndisease or diabetes mellitus will be recruited from the general population. All subjects are consented to undergo a\ndetailed on-line questionnaire, basic blood investigations, resting and continuous electrocardiogram and blood\npressure monitoring, activity and sleep tracking, calcium score, cardiac magnetic resonance imaging, whole\ngenome sequencing and lipidomic analysis. Outcomes studied will include mortality and cause of mortality,\nmyocardial infarction, stroke, malignancy, heart failure, and the development of co-morbidities.\nDiscussion: An initial target of 2500 patients has been set. From October 2015 to May 2017, an initial 683 subjects\nhave been recruited and have completed the initial work-up the SingHEART project is the first contemporary\npopulation-based study in Asia that will include whole genome sequencing and deep phenotyping: including\nadvanced imaging and wearable data, to better understand the development of cardiovascular disease across\ndifferent ethnic groups in Asia.
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